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The intrinsically disordered interdomain region between the helicase and nuclease domains of an archaeal Hef protein from Thermococcus kodakarensis was shown to be involved in interactions with multiple proteins including PCNA1 and a RecJ-like protein, suggesting that Hef acts as a scaffold and uses this IDR for sequential interaction with several proteins to control the repair pathway at the stalled fork (Ishino et al., 2014)

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Pregnancy: Iron dextran has been shown to be teratogenic and embryocidal in mice, rats, rabbits, dogs, and monkeys when given in doses of about 3 times the maximum human dose

& Yingmo, S